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Mitochondrial Metabolism and mtDNA regulation
We will define the role of metabolism in the regulation of mtDNA homeostasis and mitochondrial function.
Metabolic spatial organization of
mtDNA nucleoids
Metabolic control and resource allocation
in health and disease
Metabolic regulation of mtDNA size across scales
We combine advanced imaging, metabolic profiling, cellular stress and disease models to uncover new principles of metabolic regulation of mtDNA and mitochondrial function across yeast, mammalian cells, and mouse models. We also aim to integrate evolutionary and mathematical frameworks to understand how long-term metabolic pressures shape mtDNA size.
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